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permalink proofmathisbeautiful: scienceisbeauty: Drosophila gene expression data exploration and visualization (link) Source: Lawrence Berkeley National Laboratory

proofmathisbeautiful: scienceisbeauty:

Drosophila gene expression data exploration and visualization (link)

Source: Lawrence Berkeley National Laboratory

Posted in drosophila genetics genes gene expression science research biology
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permalink DROSOPHILA IMAGE 2008 WINNER Global Analysis of mRNA LocalizationWhile mRNA localization is known to play important roles in the establishment of cellular asymmetries, it is generally thought to be a rare phenomenon limited to specialized transcripts. To assess the overall variety and prevalence of mRNA localization events on a genomic level, we conducted a high-resolution FISH analysis of approximately 25% of mRNAs encoded in the Drosophila genome. We found that the majority of sampled mRNAs (71%) are subcellularly localized and that transcripts with similar localization patterns are often functionally related. Some of the striking and diverse patterns observed in the early embryo are illustrated in this journal cover image, with mRNAs depicted in blue and nuclei in red. This study suggests that mRNA localization is a widespread biological mechanism for organizing localized cellular machineries. An accompanying database provides a powerful resource for predicting gene function and for further characterizing mRNA localization pathways.Eric Lécuyer, Hideki Yoshida, Neela Parthasarathy, Christina Alm, Tomas Babak, Tanja Cerovina, Timothy R. Hughes, Pavel Tomancak, and Henry M. Krause. (2007) Global Analysis or mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function. Cell 131:174-187.

DROSOPHILA IMAGE 2008 WINNER

Global Analysis of mRNA Localization

While mRNA localization is known to play important roles in the establishment of cellular asymmetries, it is generally thought to be a rare phenomenon limited to specialized transcripts. To assess the overall variety and prevalence of mRNA localization events on a genomic level, we conducted a high-resolution FISH analysis of approximately 25% of mRNAs encoded in the Drosophila genome. We found that the majority of sampled mRNAs (71%) are subcellularly localized and that transcripts with similar localization patterns are often functionally related. Some of the striking and diverse patterns observed in the early embryo are illustrated in this journal cover image, with mRNAs depicted in blue and nuclei in red. This study suggests that mRNA localization is a widespread biological mechanism for organizing localized cellular machineries. An accompanying database provides a powerful resource for predicting gene function and for further characterizing mRNA localization pathways.

Eric Lécuyer, Hideki Yoshida, Neela Parthasarathy, Christina Alm, Tomas Babak, Tanja Cerovina, Timothy R. Hughes, Pavel Tomancak, and Henry M. Krause. (2007) Global Analysis or mRNA Localization Reveals a Prominent Role in Organizing Cellular Architecture and Function. Cell 131:174-187.

Posted in drosophila genetics mRNA FISH cells science competition research
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permalink Drosy, I want to kill you ‘cause I (awfully) love you. scienceisbeauty: A pair of cholinergic interneurons labelled by GFP expression in the larval nervous system of Drosophila. These intersegmental interneurons have been selectively revealed using a genetic technique to fractionate the complete set of cholinergic interneurons. Source: University of Cambridge (Cambridge Neuroscience)

Drosy, I want to kill you ‘cause I (awfully) love you.

scienceisbeauty:

A pair of cholinergic interneurons labelled by GFP expression in the larval nervous system of Drosophila. These intersegmental interneurons have been selectively revealed using a genetic technique to fractionate the complete set of cholinergic interneurons.

Source: University of Cambridge (Cambridge Neuroscience)

Posted in drosophila genetics gfp neurons nervous system
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permalink Lunedì 14 Dicembre 2009   18:45 Ho estratto cromosomi politelici tramite schiacciamento di cellule giganti di ghiandole salivari, isolate smembrando con ago una larva terzo stadio di Drosophila Melanogaster. [e ho anche selezionato mutanti e maschi da femmine, senza commettere alcun errore] Ed ero alienata, mi è sembrato di smembrare larve e spostare adulti lavorando unicamente al microscopio da sempre. E mi è sembrato naturale. Credo di non esser mai stata così serena. E ho sognato che..

Lunedì 14 Dicembre 2009   18:45

Ho estratto cromosomi politelici tramite schiacciamento di cellule giganti di ghiandole salivari, isolate smembrando con ago una larva terzo stadio di Drosophila Melanogaster.

[e ho anche selezionato mutanti e maschi da femmine, senza commettere alcun errore]

Ed ero alienata, mi è sembrato di smembrare larve e spostare adulti lavorando unicamente al microscopio da sempre. E mi è sembrato naturale.

Credo di non esser mai stata così serena.

E ho sognato che..

Posted in drosophila lab mine
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